The E4500 includes four gas sensors to detect oxygen (O2), carbon monoxide (CO), nitrogen oxide (NO), and sulfur dioxide (CO2). Additional features include a dilution pump for CO auto-range, measurement up to 50 000 ppm, automatic data saving, and internal data memory for 2000 tests.

The E4500-S can also measure temperature and pressure and comes with USB and Bluetooth connectivity. A built-in printer and full colour graphic display complete the E4500-S.